Little Known Facts About ceesdekker.
Little Known Facts About ceesdekker.
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Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Like a individual, I have the biblical assignment to investigate and use anything in generation for the benefit of my neighbour. I usually do not practical experience any conflict between faith and science. On the contrary, my faith stimulates me to try and do science, to generally be open-minded on earth.’
Deposition and atomic force microscopy of individual phthalocyanine polymers concerning nanofabricated electrodes
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SMC complexes can pass physical roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
Many related developments followed, exactly where our group set up various transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled several transistors into modest proof-of-theory electronic circuits.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; development of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the very first biosensors made outside of a carbon nanotube; fixed the framework and mechanism of DNA restore proteins; and discovery of a new system for fabricating good-point out nanopores for DNA translocation
Dekker started off his investigation on single carbon nanotubes in 1993 when he arrange a different line of analysis to study electrical transportation via one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was attained in a collaboration Along with the group of Nobel laureate Richard Smalley. STM and nanolithography techniques were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.
Testing pseudotopological and nontopological styles for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
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2008, very first observation of protein-coated DNA translocation by way of nanopores; settled the origin in the electrophoretic power ceesdekker on DNA in nanopores; identified a substantial velocity boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, managed shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous fluctuations within the handedness of histone tetrasomes